Clinical Molecular Science and Hereditary Diseases: Signaling, Diagnostic, and Management Contexts

The current book is a unique resource vividly presenting the molecular aspects of hereditary disorders, and discussing the dietary impact and management options in the light of preclinical and clinical evidence. This book also provides some insights into how posttranslational modifications (e.g. glycosylation and phosphorylation) on membrane-bound proteins are instrumental in the heterogeneity of developmental disorders. As a very limited number of efforts have made to cover these facets, this book will appeal to the enormous number of readers, including geneticists, paediatricians, pharmacists, chemists, healthcare professionals, and medical students.

This book provides information to address important questions. Why non-invasive screening protocols are beneficial for early-age patients of inherited disorders? Does the synergy of charge and polarity features of a mutant amino acid and its penultimate residues collectively induce constitutive glycosylation and underlying diverse pathology? What are the possible mechanisms behind phenotypic heterogeneity, and disease progression and severity? In what way sequence and anomeric features of glycans are decisive in developing novel treatments for hereditary diseases? How pharmacology of multi-targeting molecules and their combined therapeutic potential provide fascinating lessons to learn in hereditary diseases? Does herbal chemistry carry adjuvant antioxidant potential to scavenge free radicals and regain the delicate homeostatic balance between antioxidants and oxidants in hereditary diseases? Why is there a growing need for future research on affordable and efficacious multiple intervention systems comprising nutritional, physical, educational, behavioral, therapeutical, and digital and electrical interventions to maximize benefits to hereditary disorder patients? Such an important blend of signaling, screening, and management contexts of hereditary disorders will make this book more appealing to the readers.

Keywords: Artificial Intelligence and Neural Activity, Antioxidants, Autosomal Disorders, Challenges and Advancements in Hereditary Disorders, Congenital Anomalies, Cystic Fibrosis, Dietary Interventions, Food Chemistry, Gene Modifiers, Glycosylation, Heritable Connective Tissue Disorders, Hereditary Disorders  Management, Lysosomal Storage Disorders, Medicinal Herbs, Mendelian Puzzles, Molecular Genetics, Mucopolysaccharidosis, Natural Products, Neurological Impairments, Non-invasive Screening, Nutrition, Phosphorylation, PTMs and Disease Signaling, Saliva Screening, Sweat, Urinary Analysis.

A special discount offer on this author's books is available for university and college students, faculty, researchers, scientists, and libraries.

Publisher - Dr. Muhammad Ramzan Manwar

Author(s) - Dr. Muhammad Ramzan Manwar

Paperback

Published Date - February 20 2024

ISBN - 9781738513413

Dimensions - 27.9 x 21.6 x 0.7 cm

Page Count - 120